2 edition of Studies on the invasiveness of salmonelle typhimurium in the context of gastroenteritis found in the catalog.
Studies on the invasiveness of salmonelle typhimurium in the context of gastroenteritis
Gillian Rosemary Douce
Thesis (Ph.D) - University of Birmingham, School of Biological Sciences.
|Statement||by Gillian RosemaryDouce.|
Salmonella typhimurium is of family Enterobacteriaceae and is a gram negative rod; motile, aerobic and facultatively anaerobic; serological identification of somatic, flagellar and Vi antigens. It is one of the non-typhoid strains of salmonella common in the US. Salmonellosis is an acute. Quantitative experiments on the interaction of Salmonella choleraesuis and Salmonella dublin with porcine and bovine intestinal epithelia yielded no evidence to suggest that host restriction of S. choleraesuis and S. dublin for pigs and calves respectively could be explained in terms of the patterns of intestinal invasion observed in ligated ileal loops in vivo, at 3 h after by:
Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. A retrospective study identifying all children Cited by: 2. Non-typhoidal Salmonella (NTS) are highly prevalent food-borne pathogens. Recently, a highly invasive, multi-drug resistant S. Typhimurium, ST, emerged as Cited by: 2.
Request PDF | Salmonella Genomes in the Context of Lifestyle | The Enterobacteriaceae encompass a large family of Gram-negative gastrointestinal resident bacteria, including the Salmonella. Salmonella Typhi pathogenesis Invade SI, but usually without inflammation. Survive within macrophages and colonize liver, spleen, and can permanently live in gall bladder.
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Invasiveness of Salmonella serotypes Typhimurium and Enteritidis of human gastro-enteritic origin for rabbit ileum: role of LPS, plasmids and host factors December Journal of Medical. Invasive strains of nontyphoidal Salmonella, such as Typhimurium variant ST, emerging in areas of sub-Saharan Africa, have shown resistance to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, and cephalosporins.
Odds Ratios of Salmonella Typhimurium Infection in Case Patients vs. Controls in 12 States in Study 1, January 3–4,According to Ingested Food Item.
Study 1 Cited by: Patterns of invasiveness of Salmonella serotypes Typhimurium, Choleraesuis and Dublin in Caco-2 cells (without centrifugation) were compared with previously published studies of the rabbit ileal invasion assay (RIIA) and (where relevant) a HEp-2 cell invasion by: Invasiveness of Salmonella serotypes Typhimurium, Choleraesuis and Dublin for rabbit terminal ileum in vitro Article (PDF Available) in Journal of Medical Microbiology 48(9) October Salmonella enterica serovar Typhimurium is a Gram-negative, facultative anaerobe which causes a systemic infection in mice that resembles typhoid fever caused by S.
enterica serovar Typhi in humans. Infection by Salmonella Typhimurium results in a self-limiting gastroenteritis Cited by: 3.
The diseases caused by S. enterica serovar Typhimurium have got public health significance, as well as being associated with food poisoning in humans. Salmonellosis in humans is mainly caused by S.
typhimurium. The ability of this serovar to infect birds and contaminate eggs makes it a potent infection agent for by: 9. The formation of filamentous appendages on Salmonella typhimurium has been implicated in the triggering of bacterial entry into host cells (C.
Ginocchio, S. Olmsted, C. Wells, and J. The overall incidence of NTS in children varied markedly by location and declined significantly during the study period; the pattern of dominance of the NTS serotypes also shifted from Salmonella Enteritidis to Salmonella Typhimurium.
Risk factors for invasive NTS disease were human immunodeficiency virus infection, malaria, and malnutrition; the case fatality ratio was Cited by: Salmonella enterica serovar Typhimurium is a primary enteric pathogen infecting both humans and animals.
Infection begins with the ingestion of contaminated food or water so that salmonellae reach the intestinal epithelium and trigger gastrointestinal by: A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.
Invasion of HeLa cells by Salmonella typhimurium: a model for study of invasiveness of Salmonella. J Infect Dis. Jul; (1)– Ginocchio C, Pace J, Galán JE. Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells.
Studies of bacteraemia have suggested that invasive non-typhoidal salmonellae are among the most common isolates from febrile presentations in adults and children across sub-Saharan Africa, especially where HIV prevalence is high (figure 1).
3 The patchy availability of high-quality or affordable diagnostic microbiology facilities throughout Africa makes accurate documentation of the incidence of invasive non-typhoidal salmonella Cited by: Unrooted maximum-likelihood tree showing the relationship between isolates associated with invasive disease and gastroenteritis.
Lineages of human invasive Salmonella Typhimurium Cited by: Clinical syndromes caused by Salmonella infection in humans are divided into typhoid fever, caused by Salmonella typhi and Salmonella paratyphi, and a range of clinical syndromes, including diarrhoeal disease, caused by a large number of non-typhoidal salmonella serovars (NTS).Typhoid is a human-restricted and highly adapted invasive disease, but shows little association with by: The bacterial genus Salmonella causes a huge global burden of morbidity and mortality.
With regard to human disease, salmonellae are divided into typhoidal serotypes (Salmonella enterica var Typhi [S Typhi] and Salmonella enterica var Paratyphi A [S Paratyphi A]) and thousands of non-typhoidal salmonella serotypes (frequently referred to as NTS serotypes; panel).Cited by: Most persons infected with Salmonella bacteria develop diarrhea, fever, and abdominal cramps 12 to 72 hours after infection.
The illness usually lasts 4 to 7 days, and most persons recover without treatment. However, in some persons, the diarrhea may. Biological and genetic characterization of TnphoA mutants of Salmonella typhimurium TML in the context of gastroenteritis.
J Lodge, G R Douce, I I Amin, Douce GR, Osborne MP, Stephen J. Quantitative studies of invasion of rabbit ileal mucosa by Salmonella typhimurium strains which differ in virulence in a model of by: Decades after the early industrial era, nontyphoidal salmonella emerged as a common cause of illness.
Much of this increase is accounted for by two serotypes, Salmonella Enteritidis and Salmonella Typhimurium, which now account for nearly half of all cases of salmonellosis in the United States and for 82% of all cases of salmoneIlosis in a recent global by: Contributing to this book are internationally renowned scientists who have provided a diverse and global perspective of the issues of concern with the Salmonella pathogen.
This book serves as an excellent resource for those interested in Salmonella. In fact, this book is intended to be primarily a reference book. However, it also summarizes.
Serovars of Salmonella enterica cause infections in a diverse range of hosts. In humans, Salmonella are responsible for a broad range of clinical presentations, from gastroenteritis to invasion of normally sterile compartments such as the bloodstream or brain.
Two serovars, Salmonella Typhi and Salmonella Paratyphi A, are particularly associated with both human-restricted and invasive by: Salmonella enterica infections are common causes of bloodstream infection in low-resource areas, where they may be difficult to distinguish from other febrile illnesses and may be associated with a high case fatality ratio.
Microbiologic culture of blood or bone marrow remains the mainstay of laboratory diagnosis. Antimicrobial resistance has emerged in Salmonella enterica, Cited by: Salmonella enterica serovar Typhimurium can be classified as a Class 3 pathogen, based on the Damage Response Framework classification system, because it causes a response in all host cells along the continuum of host immune response, but causes significantly more damage in the setting of weak or strong host immune responses.